Reactome | Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer

Schema > Reaction > Entries

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
dbId	1250475
displayName	Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[Complex:R-NUL-1250499] GRB2:Sos1 [cytosol] [Complex:R-RNO-1250496] P-Erbb2mut dimer [plasma membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1250467] Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer
orthologousEvent	[Reaction:R-HSA-1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - Homo sapiens
output	[Complex:R-NUL-1250478] GRB2:Sos1:P-Erbb2mut [plasma membrane]
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus [Species:48895] Rattus norvegicus
stId	R-NUL-1250475
summation	[Summation:1250465] Exogenously expressed human GRB2 in complex with mouse Sos1 ...

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