Reactome | Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut

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Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1250506] guanyl-nucleotide exchange factor activity of GRB2:Sos1:P-Shc1:P-Erbb2mut [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
dbId	1250472
displayName	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-1250493] Ras:GDP [plasma membrane]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1250467] Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut
orthologousEvent	[Reaction:R-HSA-1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers - Homo sapiens
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-1250491] Ras:GTP [plasma membrane]
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus [Species:48895] Rattus norvegicus
stId	R-NUL-1250472
summation	[Summation:1250461] Sos1 bound to exogenously expressed human GRB2 in complex wi...
updateTrackers	[UpdateTracker:9777536] Update Tracker - [Reaction:1250472] Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut - v70:[modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9777536] Update Tracker - [Reaction:1250472] Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut - v70:[modifyText]

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