RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers

Stable Identifier
R-HSA-1250463
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SOS1, bound to GRB2 in complex with phosphorylated SHC1 and phosphorylated ERBB2 dimers, catalyzes guanyl-nucleotide exchange on RAS (Xie et al. 1995).
Literature References
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]

Inferred From
Authored
Reviewed
Created
Cite Us!