RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers

Stable Identifier
R-HSA-1250463
Type
Reaction
Species
Homo sapiens
Compartment
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SOS1, bound to GRB2 in complex with phosphorylated SHC1 and phosphorylated ERBB2 dimers, catalyzes guanyl-nucleotide exchange on RAS (Xie et al. 1995).

Literature References
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]

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