SOS1, bound to GRB2 in complex with phosphorylated SHC1 and phosphorylated ERBB2 dimers, catalyzes guanyl-nucleotide exchange on RAS (Xie et al. 1995).
Pendergast, AM, Xie, Y, Hung, MC
guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]
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