Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants

Stable Identifier
R-HSA-1247842
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants
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Once phosphorylated, PLC-gamma 1 is expected to dissociate from phosphorylated EGFR cancer mutants and induce downstream signaling in the same way it does when activated by the wild-type EGFR. However, except for the phosphorylation of PLCG1 binding site in EGFR cancer mutants, other events involved in activation of PLCG1 signaling have not been studied in cells expressing EGFR cancer mutants.
Literature References
PubMed ID Title Journal Year
15284455 Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

Bell, DW, Sordella, R, Haber, DA, Settleman, J

Science 2004
Participants
Input
Output
Participates
as an event of
Normal reaction
Active PLC-gamma1 dissociates from EGFR (Homo sapiens)
Functional status

Gain of function of Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-04-07)
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