Reactome | Hemoglobin A is protonated and carbamated causing release of oxygen

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Hemoglobin A is protonated and carbamated causing release of oxygen Show undefined attributes

authored	[InstanceEdit:1237041] May, B, 2011-03-30
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1237326] May, B, 2011-03-30
dbId	1237325
displayName	Hemoglobin A is protonated and carbamated causing release of oxygen
edited	[InstanceEdit:1237041] May, B, 2011-03-30
eventOf	[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113528] CO2 [cytosol] 4 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-HSA-1237320] OxyHbA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1237281] Human whole-blood O2 affinity: effect of CO2 [LiteratureReference:1237290] The specific influence of carbon dioxide and carbamate compounds on the buffer power and Bohr effects in human haemoglobin solutions [LiteratureReference:1237296] Electrostatic modification at the amino termini of hemoglobin A [LiteratureReference:1237208] Carbon 13 resonances of 13CO2 carbamino adducts of alpha and beta chains in human adult hemoglobin [LiteratureReference:1237199] Quantitative determination of carbamino adducts of alpha and beta chains in human adult hemoglobin in presence and absence of carbon monoxide and 2,3-diphosphoglycerate [LiteratureReference:1237228] Interaction of 13 CO 2 and bicarbonate with human hemoglobin preparations [LiteratureReference:1237224] Carbamino compounds of haemoglobin in human adult and foetal blood [LiteratureReference:1237246] Protonation states of buried histidine residues in human deoxyhemoglobin revealed by neutron crystallography [LiteratureReference:1237275] Direct determination of protonation states of histidine residues in a 2 A neutron structure of deoxy-human normal adult hemoglobin and implications for the Bohr effect [LiteratureReference:1237305] Protonation states of histidine and other key residues in deoxy normal human adult hemoglobin by neutron protein crystallography [LiteratureReference:1237294] Assessment of roles of surface histidyl residues in the molecular basis of the Bohr effect and of beta 143 histidine in the binding of 2,3-bisphosphoglycerate in human normal adult hemoglobin [LiteratureReference:1247647] Erratum to: Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels [LiteratureReference:1247646] Thermal studies of the rates of the reactions of carbon dioxide in concentrated haemoglobin solutions and in red blood cells. A. The reactions catalysed by carbonic anhydrase. B. The carbamino reactions of oxygenated and deoxygenated haemoglobin [LiteratureReference:1247662] The chemical relationships and physiological importance of carbamino compounds of CO(2) with haemoglobin [LiteratureReference:1247678] Reaction of CO2 with human hemoglobin solution
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Hemoglobin A is protonated and carbamated causing release of oxygen Bohr Effect
orthologousEvent	[Reaction:R-GGA-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Gallus gallus [Reaction:R-XTR-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Xenopus tropicalis [Reaction:R-SSC-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Sus scrofa [Reaction:R-BTA-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Bos taurus [Reaction:R-CFA-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Canis familiaris [Reaction:R-RNO-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Rattus norvegicus [Reaction:R-MMU-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Mus musculus
output	4 × [SimpleEntity:R-ALL-29368] O2 [cytosol] [Complex:R-HSA-1237312] Protonated Carbamino DeoxyHbA [cytosol]
precedingEvent	[Reaction:R-HSA-1237069] RHAG transports CO2 from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Homo sapiens
releaseDate	2012-06-12
reverseReaction	[Reaction:R-HSA-1247668] Hemoglobin A binds O2, releasing H+ and CO2
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2207684] Jassal, B, 2012-04-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1237325
summation	[Summation:1244357] The Bohr effect refers to the observation that carbon dioxid...

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(hasEvent)

[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen

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