Reactome | Erythrocytes take up carbon dioxide and release oxygen

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Erythrocytes take up carbon dioxide and release oxygen Show undefined attributes

authored	[InstanceEdit:1237008] May, B, 2011-03-24
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1237041] May, B, 2011-03-30
dbId	1237044
displayName	Erythrocytes take up carbon dioxide and release oxygen
edited	[InstanceEdit:1237008] May, B, 2011-03-24
eventOf	[Pathway:R-HSA-1480926] O2/CO2 exchange in erythrocytes - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24814] bicarbonate transport
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Homo sapiens [Reaction:R-HSA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-1237069] RHAG transports CO2 from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-1475435] CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- - Homo sapiens [Reaction:R-HSA-9707419] CA1:Zn2+,CA2:Zn2+ bind CA inhibitors - Homo sapiens [Reaction:R-HSA-1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- - Homo sapiens [Reaction:R-HSA-1237325] Hemoglobin A is protonated and carbamated causing release of oxygen - Homo sapiens [Reaction:R-HSA-6806831] CYB5Rs reduce MetHb to HbA - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1237544] Evaluating the role of carbonic anhydrases in the transport of HCO3--related species [LiteratureReference:1237548] Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport [LiteratureReference:1237545] Carbon dioxide transport and carbonic anhydrase in blood and muscle
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Erythrocytes take up carbon dioxide and release oxygen
orthologousEvent	[Pathway:R-PFA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Plasmodium falciparum [Pathway:R-DDI-1237044] Erythrocytes take up carbon dioxide and release oxygen - Dictyostelium discoideum [Pathway:R-CEL-1237044] Erythrocytes take up carbon dioxide and release oxygen - Caenorhabditis elegans [Pathway:R-DME-1237044] Erythrocytes take up carbon dioxide and release oxygen - Drosophila melanogaster [Pathway:R-GGA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Gallus gallus [Pathway:R-XTR-1237044] Erythrocytes take up carbon dioxide and release oxygen - Xenopus tropicalis [Pathway:R-DRE-1237044] Erythrocytes take up carbon dioxide and release oxygen - Danio rerio [Pathway:R-SSC-1237044] Erythrocytes take up carbon dioxide and release oxygen - Sus scrofa [Pathway:R-BTA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Bos taurus [Pathway:R-CFA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Canis familiaris [Pathway:R-RNO-1237044] Erythrocytes take up carbon dioxide and release oxygen - Rattus norvegicus [Pathway:R-MMU-1237044] Erythrocytes take up carbon dioxide and release oxygen - Mus musculus
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2207684] Jassal, B, 2012-04-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1237044
summation	[Summation:1244344] Carbon dioxide (CO2) in plasma is hydrated to yield protons ...

Referrals

(normalPathway)	[Pathway:R-HSA-5619050] Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
(hasEvent)	[Pathway:R-HSA-1480926] O2/CO2 exchange in erythrocytes

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