Reactome | Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7

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Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 Show undefined attributes

authored	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
dbId	114392
displayName	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
edited	[InstanceEdit:9627414] Shamovsky, Veronica, 2018-11-02
eventOf	[Pathway:R-HSA-111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9029680] Caspase-7 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-201634] Caspase-mediated cleavage of FADK 1 - Homo sapiens [Reaction:R-HSA-201639] Caspase-mediated cleavage of GAS2 - Homo sapiens [Reaction:R-HSA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) - Homo sapiens
input	[Complex:R-HSA-114353] DIABLO:XIAP:Caspase-7 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:114476] Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
orthologousEvent	[Reaction:R-HSA-114440] Dissociation of DIABLO:XIAP from the apoptosome complex - Homo sapiens [Reaction:R-HSA-114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 - Homo sapiens [Reaction:R-GGA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Gallus gallus [Reaction:R-DRE-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Danio rerio [Reaction:R-SSC-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Sus scrofa [Reaction:R-BTA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Bos taurus [Reaction:R-CFA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Canis familiaris [Reaction:R-RNO-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Rattus norvegicus [Reaction:R-MMU-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Mus musculus
output	[Complex:R-HSA-141643] Caspase-7 [cytosol] [Complex:R-HSA-9627391] DIABLO dimer:XIAP [cytosol]
precedingEvent	[Reaction:R-HSA-114354] SMAC binds XIAP:Caspase-7 - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9627969] Matthews, Lisa, 2018-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-114392
summation	[Summation:178686] The linker region preceding BIR2 of XIAP is responsible for ...
updateTrackers	[UpdateTracker:9788043] Update Tracker - [Reaction:114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - v44:[modifyText] [UpdateTracker:9778745] Update Tracker - [Reaction:114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - v67:[add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788043] Update Tracker - [Reaction:114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - v44:[modifyText] [UpdateTracker:9778745] Update Tracker - [Reaction:114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - v67:[add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
(precedingEvent)	[BlackBoxEvent:R-HSA-9029680] Caspase-7 translocates to the nucleus [Reaction:R-HSA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) [Reaction:R-HSA-201639] Caspase-mediated cleavage of GAS2 [Reaction:R-HSA-201634] Caspase-mediated cleavage of FADK 1

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