Reactome | The linker region preceding BIR2 of XIAP is responsible for ...

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created	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId	178686
displayName	The linker region preceding BIR2 of XIAP is responsible for ...
literatureReference	[LiteratureReference:9627388] XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs [LiteratureReference:9627437] Structural basis of IAP recognition by Smac/DIABLO [LiteratureReference:9627061] Structural and biochemical basis of apoptotic activation by Smac/DIABLO [LiteratureReference:114476] Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
modified	[InstanceEdit:9627414] Shamovsky, Veronica, 2018-11-02
schemaClass	Summation
text	The linker region preceding BIR2 of XIAP is responsible for the inhibition of caspase-3 and -7, which is further stabilized by interaction with the BIR2 domain itself (Scott et al. 2005). Binding of a dimeric SMAC (DIABLO) N-terminal peptide with the BIR2 domain of XIAP effectively antagonized inhibition of caspase-7 by XIAP (Wu G et al. 2000; Chai J et al. 2000). As DIABLO has a higher affinity for the BIR2 domain than caspase-7, DIABLO (SMAC) binding to XIAP results in the liberation of caspase-7 (Huang et al. 2001).

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