Reactome | Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7

Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7

Stable Identifier

R-HSA-114392

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - SMAC, XIAP-regulated apoptotic response (Homo sapiens)
        
        SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Homo sapiens)
        
        Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)

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Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7

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The linker region preceding BIR2 of XIAP is responsible for the inhibition of caspase-3 and -7, which is further stabilized by interaction with the BIR2 domain itself (Scott et al. 2005). Binding of a dimeric SMAC (DIABLO) N-terminal peptide with the BIR2 domain of XIAP effectively antagonized inhibition of caspase-7 by XIAP (Wu G et al. 2000; Chai J et al. 2000). As DIABLO has a higher affinity for the BIR2 domain than caspase-7, DIABLO (SMAC) binding to XIAP results in the liberation of caspase-7 (Huang et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11257231	Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain Huang, Y, Wu, H, Rich, RL, Park, YC, Myszka, DG, Segal, D	Cell	2001