Reactome | Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7

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Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9992934
displayName	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
eventOf	[Pathway:R-MMU-111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-9029680] Caspase-7 translocates to the nucleus - Mus musculus [Reaction:R-MMU-201634] Caspase-mediated cleavage of FADK 1 - Mus musculus [Reaction:R-MMU-201639] Caspase-mediated cleavage of GAS2 - Mus musculus [Reaction:R-MMU-201628] Caspase-mediated cleavage of vimentin at DSVD (85) - Mus musculus
inferredFrom	[Reaction:R-HSA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Homo sapiens
input	[Complex:R-MMU-114353] DIABLO:XIAP:Caspase-7 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
output	[Complex:R-MMU-141643] Caspase-7 [cytosol] [Complex:R-MMU-9627391] DIABLO dimer:XIAP [cytosol]
precedingEvent	[Reaction:R-MMU-114354] SMAC binds XIAP:Caspase-7 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-114392
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
(precedingEvent)	[BlackBoxEvent:R-MMU-9029680] Caspase-7 translocates to the nucleus [Reaction:R-MMU-201628] Caspase-mediated cleavage of vimentin at DSVD (85) [Reaction:R-MMU-201639] Caspase-mediated cleavage of GAS2 [Reaction:R-MMU-201634] Caspase-mediated cleavage of FADK 1
(inferredTo)	[Reaction:R-HSA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7