Reactome | SMAC binds XIAP:Caspase-7

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SMAC binds XIAP:Caspase-7 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
dbId	114354
displayName	SMAC binds XIAP:Caspase-7
edited	[InstanceEdit:9628217] Shamovsky, Veronica, 2018-11-07
eventOf	[Pathway:R-HSA-111463] SMAC (DIABLO) binds to IAPs - Homo sapiens
followingEvent	[Reaction:R-HSA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Homo sapiens
input	[Complex:R-HSA-9627054] DIABLO dimer [cytosol] [Complex:R-HSA-114308] XIAP:Caspase-7 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:114476] Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain [LiteratureReference:114477] X-linked IAP is a direct inhibitor of cell-death proteases. [LiteratureReference:114474] Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. [LiteratureReference:6804352] A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SMAC binds XIAP:Caspase-7
orthologousEvent	[Reaction:R-HSA-114361] SMAC binds XIAP within apoptosome - Homo sapiens [Reaction:R-HSA-114306] SMAC binds XIAP:Caspase-3 - Homo sapiens [Reaction:R-GGA-114354] SMAC binds XIAP:Caspase-7 - Gallus gallus [Reaction:R-DRE-114354] SMAC binds XIAP:Caspase-7 - Danio rerio [Reaction:R-SSC-114354] SMAC binds XIAP:Caspase-7 - Sus scrofa [Reaction:R-BTA-114354] SMAC binds XIAP:Caspase-7 - Bos taurus [Reaction:R-CFA-114354] SMAC binds XIAP:Caspase-7 - Canis familiaris [Reaction:R-RNO-114354] SMAC binds XIAP:Caspase-7 - Rattus norvegicus [Reaction:R-MMU-114354] SMAC binds XIAP:Caspase-7 - Mus musculus
output	[Complex:R-HSA-114353] DIABLO:XIAP:Caspase-7 [cytosol]
precedingEvent	[Reaction:R-HSA-114307] Release of SMAC (DIABLO) from mitochondria - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9627969] Matthews, Lisa, 2018-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-114354
summation	[Summation:179178] The linker region preceding BIR2 of XIAP is responsible for ...
updateTrackers	[UpdateTracker:9783932] Update Tracker - [Reaction:114354] SMAC binds XIAP:Caspase-7 - v55:[addLiteratureReference] [UpdateTracker:9778942] Update Tracker - [Reaction:114354] SMAC binds XIAP:Caspase-7 - v67:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783932] Update Tracker - [Reaction:114354] SMAC binds XIAP:Caspase-7 - v55:[addLiteratureReference] [UpdateTracker:9778942] Update Tracker - [Reaction:114354] SMAC binds XIAP:Caspase-7 - v67:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-111463] SMAC (DIABLO) binds to IAPs
(precedingEvent)	[Reaction:R-HSA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7

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