Reactome | SMAC (DIABLO) binds to IAPs

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
crossReference	[DatabaseIdentifier:12819577] BioModels Database:BIOMD0000000256 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407
dbId	111463
displayName	SMAC (DIABLO) binds to IAPs
edited	[InstanceEdit:9628218] Shamovsky, Veronica, 2018-11-07
eventOf	[Pathway:R-HSA-111469] SMAC, XIAP-regulated apoptotic response - Homo sapiens
followingEvent	[Pathway:R-HSA-111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9627350] SMAC (DIABLO) binds XIAP - Homo sapiens [Reaction:R-HSA-114306] SMAC binds XIAP:Caspase-3 - Homo sapiens [Reaction:R-HSA-114354] SMAC binds XIAP:Caspase-7 - Homo sapiens [Reaction:R-HSA-114361] SMAC binds XIAP within apoptosome - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-12-13
literatureReference	[LiteratureReference:140369] IAP proteins: blocking the road to death's door
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	SMAC (DIABLO) binds to IAPs
orthologousEvent	[Pathway:R-GGA-111463] SMAC (DIABLO) binds to IAPs - Gallus gallus [Pathway:R-DRE-111463] SMAC (DIABLO) binds to IAPs - Danio rerio [Pathway:R-SSC-111463] SMAC (DIABLO) binds to IAPs - Sus scrofa [Pathway:R-BTA-111463] SMAC (DIABLO) binds to IAPs - Bos taurus [Pathway:R-CFA-111463] SMAC (DIABLO) binds to IAPs - Canis familiaris [Pathway:R-RNO-111463] SMAC (DIABLO) binds to IAPs - Rattus norvegicus [Pathway:R-MMU-111463] SMAC (DIABLO) binds to IAPs - Mus musculus
precedingEvent	[Reaction:R-HSA-114307] Release of SMAC (DIABLO) from mitochondria - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9620504] Matthews, Lisa, 2018-09-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-111463
summation	[Summation:212960] Second mitochondria?derived activator of caspases protein (S...
updateTrackers	[UpdateTracker:9783850] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v55:[updateContainedRLE] [UpdateTracker:9789289] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v38:[addLiteratureReference] [UpdateTracker:9778875] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v67:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9791978] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v24:[addSummation]

SMAC (DIABLO) binds to IAPs Show undefined attributes

Referrals

(updatedInstance)	[UpdateTracker:9783850] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v55:[updateContainedRLE] [UpdateTracker:9789289] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v38:[addLiteratureReference] [UpdateTracker:9778875] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v67:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9791978] Update Tracker - [Pathway:111463] SMAC (DIABLO) binds to IAPs - v24:[addSummation]
(precedingEvent)	[Pathway:R-HSA-111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
(hasEvent)	[Pathway:R-HSA-111469] SMAC, XIAP-regulated apoptotic response