Reactome | SMAC binds XIAP:Caspase-7

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SMAC binds XIAP:Caspase-7 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9992930
displayName	SMAC binds XIAP:Caspase-7
eventOf	[Pathway:R-MMU-111463] SMAC (DIABLO) binds to IAPs - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Mus musculus
inferredFrom	[Reaction:R-HSA-114354] SMAC binds XIAP:Caspase-7 - Homo sapiens
input	[Complex:R-MMU-9627054] DIABLO dimer [cytosol] [Complex:R-MMU-114308] XIAP:Caspase-7 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SMAC binds XIAP:Caspase-7
output	[Complex:R-MMU-114353] DIABLO:XIAP:Caspase-7 [cytosol]
precedingEvent	[Reaction:R-MMU-114307] Release of SMAC (DIABLO) from mitochondria - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-114354
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-111463] SMAC (DIABLO) binds to IAPs
(precedingEvent)	[Reaction:R-MMU-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
(inferredTo)	[Reaction:R-HSA-114354] SMAC binds XIAP:Caspase-7

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