Reactome | The linker region preceding BIR2 of XIAP is responsible for ...

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created	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId	179178
displayName	The linker region preceding BIR2 of XIAP is responsible for ...
literatureReference	[LiteratureReference:9627388] XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs [LiteratureReference:9627061] Structural and biochemical basis of apoptotic activation by Smac/DIABLO [LiteratureReference:9627437] Structural basis of IAP recognition by Smac/DIABLO
modified	[InstanceEdit:9627414] Shamovsky, Veronica, 2018-11-02
schemaClass	Summation
text	The linker region preceding BIR2 of XIAP is responsible for the inhibition of caspase?3 and ?7, which is further stabilized by interaction with the BIR2 domain itself (Scott et al. 2005). Binding of a dimeric SMAC (DIABLO) N?terminal peptide with the BIR2 domain of XIAP effectively antagonized inhibition of caspase?7 by XIAP (Wu G et al. 2000; Chai J et al. 2000).

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