Reactome | SMAC binds XIAP:Caspase-7

SMAC binds XIAP:Caspase-7

Stable Identifier

R-HSA-114354

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - SMAC, XIAP-regulated apoptotic response (Homo sapiens)
        
        SMAC (DIABLO) binds to IAPs (Homo sapiens)
        
        SMAC binds XIAP:Caspase-7 (Homo sapiens)

General

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The linker region preceding BIR2 of XIAP is responsible for the inhibition of caspase‑3 and ‑7, which is further stabilized by interaction with the BIR2 domain itself (Scott et al. 2005). Binding of a dimeric SMAC (DIABLO) N‑terminal peptide with the BIR2 domain of XIAP effectively antagonized inhibition of caspase‑7 by XIAP (Wu G et al. 2000; Chai J et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11257231	Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain Huang, Y, Wu, H, Rich, RL, Park, YC, Myszka, DG, Segal, D	Cell	2001
9230442	X-linked IAP is a direct inhibitor of cell-death proteases. Reed, JC, Deveraux, QL, Takahashi, R, Salvesen, GS	Nature	1997
14960576	Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. Du, C, Yang, QH	J Biol Chem	2004
18619610	A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases Davoodi, J, Abhari, BA	J. Mol. Biol.	2008