Reactome | P-TEFb complex [nucleoplasm]

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P-TEFb complex [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10234495] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm] [CatalystActivity:10277846] protein serine/threonine kinase activity of CDK8:CCNC/ CDK9:CCNT [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - Canis familiaris [Complex:R-CFA-6814541] RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] - Canis familiaris [Complex:R-CFA-6810225] Initiation factors:CDK7:snRNA gene [nucleoplasm] - Canis familiaris [Complex:R-CFA-113722] Aborted elongation complex after arrest [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10234364
displayName	P-TEFb complex [nucleoplasm]
hasComponent	[DefinedSet:R-CFA-6807466] CCNT1,CCNT2,CCNK [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-51801] CDK9 [nucleoplasm]
inDisease	false
inferredFrom	[DefinedSet:R-HSA-2176485] CDK8:CCNC/ CDK9:CCNT [nucleoplasm] - Homo sapiens [Complex:R-HSA-112431] P-TEFb complex [nucleoplasm] - Homo sapiens
maxDepth	3
name	P-TEFb complex
producedByEvent	[Reaction:R-CFA-112430] Formation of P-TEFb complex - Canis familiaris [Reaction:R-CFA-113429] Elongating transcript encounters a lesion in the template - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-112431
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-CFA-113429] Elongating transcript encounters a lesion in the template [Reaction:R-CFA-112430] Formation of P-TEFb complex
(hasComponent)	[Complex:R-CFA-6814541] RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] [Complex:R-CFA-6810225] Initiation factors:CDK7:snRNA gene [nucleoplasm] [Complex:R-CFA-113722] Aborted elongation complex after arrest [nucleoplasm] [Complex:R-CFA-113720] Paused processive elongation complex [nucleoplasm] [Complex:R-CFA-113726] Elongation complex with separated and uncleaved transcript [nucleoplasm] [Complex:R-CFA-113724] Elongation complex prior to separation [nucleoplasm] [Complex:R-CFA-113719] Processive elongation complex [nucleoplasm] [Complex:R-CFA-113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] [Complex:R-CFA-6797608] CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] [Complex:R-CFA-6797609] Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm]
(input)	[Reaction:R-CFA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
(physicalEntity)	[CatalystActivity:10234495] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm] [CatalystActivity:10277846] protein serine/threonine kinase activity of CDK8:CCNC/ CDK9:CCNT [nucleoplasm]
(inferredTo)	[DefinedSet:R-HSA-2176485] CDK8:CCNC/ CDK9:CCNT [nucleoplasm] [Complex:R-HSA-112431] P-TEFb complex [nucleoplasm]

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