Reactome | P-TEFb complex [nucleoplasm]

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P-TEFb complex [nucleoplasm]

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catalystActivities	[CatalystActivity:10098902] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-SSC-113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - Sus scrofa [Complex:R-SSC-6797608] CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] - Sus scrofa [Complex:R-SSC-6810225] Initiation factors:CDK7:snRNA gene [nucleoplasm] - Sus scrofa [Complex:R-SSC-113726] Elongation complex with separated and uncleaved transcript [nucleoplasm] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Sus scrofa
created	[InstanceEdit:10091100] Shorser, Solomon, 2020-11-20
dbId	10098769
displayName	P-TEFb complex [nucleoplasm]
hasComponent	[DefinedSet:R-SSC-6807466] CCNT1,CCNT2,CCNK [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-51801] CDK9 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-112431] P-TEFb complex [nucleoplasm] - Homo sapiens
memberOf	[DefinedSet:R-SSC-2176485] CDK8:CCNC/ CDK9:CCNT [nucleoplasm] - Sus scrofa
name	P-TEFb complex
producedByEvent	[Reaction:R-SSC-112430] Formation of P-TEFb complex - Sus scrofa [Reaction:R-SSC-113429] Elongating transcript encounters a lesion in the template - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-112431
summation	[Summation:9707412] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-SSC-113429] Elongating transcript encounters a lesion in the template - Sus scrofa [Reaction:R-SSC-112430] Formation of P-TEFb complex - Sus scrofa
(hasComponent)	[Complex:R-SSC-6814541] RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] - Sus scrofa [Complex:R-SSC-6810225] Initiation factors:CDK7:snRNA gene [nucleoplasm] - Sus scrofa [Complex:R-SSC-113722] Aborted elongation complex after arrest [nucleoplasm] - Sus scrofa [Complex:R-SSC-113720] Paused processive elongation complex [nucleoplasm] - Sus scrofa [Complex:R-SSC-113719] Processive elongation complex [nucleoplasm] - Sus scrofa [Complex:R-SSC-113726] Elongation complex with separated and uncleaved transcript [nucleoplasm] - Sus scrofa [Complex:R-SSC-113724] Elongation complex prior to separation [nucleoplasm] - Sus scrofa [Complex:R-SSC-113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - Sus scrofa [Complex:R-SSC-6797608] CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] - Sus scrofa [Complex:R-SSC-6797609] Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] - Sus scrofa
(input)	[Reaction:R-SSC-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Sus scrofa
(physicalEntity)	[CatalystActivity:10098902] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
(hasMember)	[DefinedSet:R-SSC-2176485] CDK8:CCNC/ CDK9:CCNT [nucleoplasm] - Sus scrofa
(inferredTo)	[Complex:R-HSA-112431] P-TEFb complex [nucleoplasm] - Homo sapiens

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