Reactome | PRPS1 dimer pyrophosphorylates R5P using dATP

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PRPS1 dimer pyrophosphorylates R5P using dATP Show undefined attributes

catalystActivity	[CatalystActivity:11002308] ribose phosphate diphosphokinase activity of PRPS1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11002310
displayName	PRPS1 dimer pyrophosphorylates R5P using dATP
eventOf	[Pathway:R-DDI-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Homo sapiens
input	[SimpleEntity:R-ALL-110644] dATP [cytosol] [SimpleEntity:R-ALL-73578] R5P [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PRPS1 dimer pyrophosphorylates R5P using dATP D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate
output	[SimpleEntity:R-ALL-109386] dAMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
regulatedBy	[Requirement:R-GGA-353035] Requirement by 'Mg2+ [cytosol]' [Requirement:R-HSA-9034462] Requirement by 'Pi [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-111215
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DDI-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP
(hasEvent)	[Pathway:R-DDI-73843] 5-Phosphoribose 1-diphosphate biosynthesis
(inferredTo)	[Reaction:R-HSA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP

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