Reactome | PDPK1 phosphorylates AKT2

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PDPK1 phosphorylates AKT2 Show undefined attributes

catalystActivity	[CatalystActivity:162381] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643668] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane] Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
dbId	109702
displayName	PDPK1 phosphorylates AKT2
eventOf	[Pathway:R-HSA-165158] Activation of AKT2 - Homo sapiens
followingEvent	[Reaction:R-HSA-1458463] p-AKT2 phosphorylates RGC2 - Homo sapiens [BlackBoxEvent:R-HSA-1445144] p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) - Homo sapiens [Reaction:R-HSA-1449597] p-AKT2 phosphorylates Myosin 5A - Homo sapiens [Reaction:R-HSA-162363] p-T309,S474-AKT2:PIP3 phosphorylates PDE3B - Homo sapiens
input	[Complex:R-HSA-109696] AKT2:PIP3 [plasma membrane] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:162388] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha [LiteratureReference:162378] Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B [LiteratureReference:5686064] Activation of a GST-tagged AKT2/PKBbeta
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PDPK1 phosphorylates AKT2 Phosphorylation of PKB by PDK1
orthologousEvent	[Reaction:R-SCE-109702] PDPK1 phosphorylates AKT2 - Saccharomyces cerevisiae [Reaction:R-SPO-109702] PDPK1 phosphorylates AKT2 - Schizosaccharomyces pombe [Reaction:R-DDI-109702] PDPK1 phosphorylates AKT2 - Dictyostelium discoideum [Reaction:R-CEL-109702] PDPK1 phosphorylates AKT2 - Caenorhabditis elegans [Reaction:R-DME-109702] PDPK1 phosphorylates AKT2 - Drosophila melanogaster [Reaction:R-DRE-109702] PDPK1 phosphorylates AKT2 - Danio rerio [Reaction:R-SSC-109702] PDPK1 phosphorylates AKT2 - Sus scrofa [Reaction:R-BTA-109702] PDPK1 phosphorylates AKT2 - Bos taurus [Reaction:R-RNO-109702] PDPK1 phosphorylates AKT2 - Rattus norvegicus [Reaction:R-MMU-109702] PDPK1 phosphorylates AKT2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-162387] p-T309,S474-AKT2:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-109700] AKT2 binds PIP3 - Homo sapiens [Reaction:R-HSA-109701] PDPK1 binds PIP3 - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109702
summation	[Summation:179070] Two specific sites in AKT2, one in the kinase domain (Thr-30...
updateTrackers	[UpdateTracker:9791243] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v31:[removeLiteratureReference] [UpdateTracker:9784553] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v53:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791243] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v31:[removeLiteratureReference] [UpdateTracker:9784553] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v53:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-1458463] p-AKT2 phosphorylates RGC2 [BlackBoxEvent:R-HSA-1445144] p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) [Reaction:R-HSA-1449597] p-AKT2 phosphorylates Myosin 5A [Reaction:R-HSA-162363] p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
(hasEvent)	[Pathway:R-HSA-165158] Activation of AKT2

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