Reactome | AKT2 binds PIP3

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AKT2 binds PIP3 Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
dbId	109700
displayName	AKT2 binds PIP3
eventOf	[Pathway:R-HSA-165158] Activation of AKT2 - Homo sapiens
followingEvent	[Reaction:R-HSA-109702] PDPK1 phosphorylates AKT2 - Homo sapiens
input	[Complex:R-HSA-162401] AKT2:THEM4,TRIB3 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199452] TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver [LiteratureReference:199446] Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane [LiteratureReference:162409] Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation [LiteratureReference:162390] Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B [LiteratureReference:9028154] AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	AKT2 binds PIP3 PKB attachment to plasma membrane
orthologousEvent	[Reaction:R-DDI-109700] AKT2 binds PIP3 - Dictyostelium discoideum [Reaction:R-CEL-109700] AKT2 binds PIP3 - Caenorhabditis elegans [Reaction:R-DME-109700] AKT2 binds PIP3 - Drosophila melanogaster [Reaction:R-DRE-109700] AKT2 binds PIP3 - Danio rerio [Reaction:R-SSC-109700] AKT2 binds PIP3 - Sus scrofa [Reaction:R-BTA-109700] AKT2 binds PIP3 - Bos taurus [Reaction:R-RNO-109700] AKT2 binds PIP3 - Rattus norvegicus [Reaction:R-MMU-109700] AKT2 binds PIP3 - Mus musculus
output	[Complex:R-HSA-109696] AKT2:PIP3 [plasma membrane] [DefinedSet:R-HSA-162414] THEM4,TRIB3 [cytosol]
precedingEvent	[Reaction:R-HSA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109700
summation	[Summation:199427] The phosphorylation of membrane-recruited AKT at threonine a...
updateTrackers	[UpdateTracker:9782401] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v59:[add_removeLiteratureReference] [UpdateTracker:9780355] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v63:[addLiteratureReference, add_removeInput] [UpdateTracker:9780117] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v64:[add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9782401] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v59:[add_removeLiteratureReference] [UpdateTracker:9780355] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v63:[addLiteratureReference, add_removeInput] [UpdateTracker:9780117] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v64:[add_removeSummation]
(hasEvent)	[Pathway:R-HSA-165158] Activation of AKT2
(precedingEvent)	[Reaction:R-HSA-109702] PDPK1 phosphorylates AKT2

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