Reactome | PDPK1 phosphorylates AKT2

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PDPK1 phosphorylates AKT2 Show undefined attributes

catalystActivity	[CatalystActivity:10340066] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10340068
displayName	PDPK1 phosphorylates AKT2
eventOf	[Pathway:R-BTA-165158] Activation of AKT2 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-109702] PDPK1 phosphorylates AKT2 - Homo sapiens
input	[Complex:R-BTA-109696] AKT2:PIP3 [plasma membrane] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PDPK1 phosphorylates AKT2 Phosphorylation of PKB by PDK1
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-162387] p-T309,S474-AKT2:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-BTA-109700] AKT2 binds PIP3 - Bos taurus [Reaction:R-BTA-109701] PDPK1 binds PIP3 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-109702
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-165158] Activation of AKT2
(inferredTo)	[Reaction:R-HSA-109702] PDPK1 phosphorylates AKT2

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