Reactome | p-AKT2 phosphorylates Myosin 5A

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p-AKT2 phosphorylates Myosin 5A Show undefined attributes

authored	[InstanceEdit:1445151] May, B, 2011-07-12
catalystActivity	[CatalystActivity:1445142] protein serine/threonine kinase activity of p-T309,S474-AKT2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1449564] May, B, 2011-07-15
dbId	1449597
displayName	p-AKT2 phosphorylates Myosin 5A
edited	[InstanceEdit:1445151] May, B, 2011-07-12
eventOf	[Pathway:R-HSA-1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane - Homo sapiens [Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens
followingEvent	[Reaction:R-HSA-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Homo sapiens [BlackBoxEvent:R-HSA-2316352] SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane - Homo sapiens
inferredFrom	[Reaction:R-MMU-1449591] Akt2 Phosphorylates Myosin 5a - Mus musculus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9605111] MYO5A dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9907153] Rothfels, Karen, 2024-04-04
name	p-AKT2 phosphorylates Myosin 5A
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9605106] p-S1652-MYO5A dimer [cytosol]
precedingEvent	[Reaction:R-HSA-109702] PDPK1 phosphorylates AKT2 - Homo sapiens [BlackBoxEvent:R-HSA-9856462] MITF-M-dependent MYO5A expression - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2454132] Klip, Amira, 2012-08-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1449597
summation	[Summation:1458453] As inferred from mouse, AKT2 phosphorylates Myosin 5A on ser...
updateTrackers	[UpdateTracker:9779499] Update Tracker - [Reaction:1449597] p-AKT2 phosphorylates Myosin 5A - v65:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9779499] Update Tracker - [Reaction:1449597] p-AKT2 phosphorylates Myosin 5A - v65:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-1445148] Translocation of SLC2A4 (GLUT4) to the plasma membrane [Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation
(precedingEvent)	[BlackBoxEvent:R-HSA-2316352] SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane [Reaction:R-HSA-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A
(inferredTo)	[Reaction:R-MMU-1449591] Akt2 Phosphorylates Myosin 5a

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