Reactome | PDPK1 phosphorylates AKT2

PDPK1 phosphorylates AKT2

Stable Identifier

R-HSA-109702

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Phosphorylation of PKB by PDK1

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 phosphorylates AKT2 (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 phosphorylates AKT2 (Homo sapiens)

General

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Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Literature References

PubMed ID	Title	Journal	Year
9228007	Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B Gaffney, PR, Painter, GF, McCormick, F, Hawkins, PT, Holmes, AB, Reese, CB, Copeland, T, Stokoe, D, Stephens, LR	Science	1997
15890450	Activation of a GST-tagged AKT2/PKBbeta Lisinski, I, Klein, HW, Gompert, M, Stuhlmann, D, Schmolz, K, Baer, K, Al-Hasani, H	Biochim. Biophys. Acta	2005
9094314	Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Gaffney, PR, Cohen, P, Reese, CB, Holmes, AB, Alessi, DR, Downes, CP, James, SR	Curr Biol	1997