PDPK1 phosphorylates AKT2

Stable Identifier
Reaction [transition]
Homo sapiens
Phosphorylation of PKB by PDK1
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Literature References
PubMed ID Title Journal Year
15890450 Activation of a GST-tagged AKT2/PKBbeta

Baer, K, Lisinski, I, Gompert, M, Stuhlmann, D, Schmolz, K, Klein, HW, Al-Hasani, H

Biochim. Biophys. Acta 2005
9228007 Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

Stokoe, D, Stephens, LR, Copeland, T, Gaffney, PR, Reese, CB, Painter, GF, Holmes, AB, McCormick, F, Hawkins, PT

Science 1997
9094314 Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

Alessi, DR, James, SR, Downes, CP, Holmes, AB, Gaffney, PR, Reese, CB, Cohen, P

Curr Biol 1997
Participant Of
Catalyst Activity
Catalyst Activity
protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
Physical Entity
Orthologous Events
Cite Us!