PDPK1 phosphorylates AKT2

Stable Identifier
R-HSA-109702
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Phosphorylation of PKB by PDK1
Locations in the PathwayBrowser
General
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Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Literature References
PubMed ID Title Journal Year
15890450 Activation of a GST-tagged AKT2/PKBbeta

Baer, K, Lisinski, I, Gompert, M, Stuhlmann, D, Schmolz, K, Klein, HW, Al-Hasani, H

Biochim. Biophys. Acta 2005
9228007 Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

Stokoe, D, Stephens, LR, Copeland, T, Gaffney, PR, Reese, CB, Painter, GF, Holmes, AB, McCormick, F, Hawkins, PT

Science 1997
9094314 Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

Alessi, DR, James, SR, Downes, CP, Holmes, AB, Gaffney, PR, Reese, CB, Cohen, P

Curr Biol 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Created