PDPK1 phosphorylates AKT2

Stable Identifier
R-HSA-109702
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Phosphorylation of PKB by PDK1
Locations in the PathwayBrowser
General
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Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Literature References
PubMed ID Title Journal Year
9228007 Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

Gaffney, PR, Painter, GF, McCormick, F, Hawkins, PT, Holmes, AB, Reese, CB, Copeland, T, Stokoe, D, Stephens, LR

Science 1997
15890450 Activation of a GST-tagged AKT2/PKBbeta

Lisinski, I, Klein, HW, Gompert, M, Stuhlmann, D, Schmolz, K, Baer, K, Al-Hasani, H

Biochim. Biophys. Acta 2005
9094314 Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

Gaffney, PR, Cohen, P, Reese, CB, Holmes, AB, Alessi, DR, Downes, CP, James, SR

Curr Biol 1997
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]

Orthologous Events
Created
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