Reactome | PDPK1 phosphorylates AKT2

PDPK1 phosphorylates AKT2

Stable Identifier

R-HSA-109702

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Phosphorylation of PKB by PDK1

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 phosphorylates AKT2 (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        Activation of AKT2 (Homo sapiens)
        
        PDPK1 phosphorylates AKT2 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Literature References

PubMed ID	Title	Journal	Year
15890450	Activation of a GST-tagged AKT2/PKBbeta Baer, K, Lisinski, I, Gompert, M, Stuhlmann, D, Schmolz, K, Klein, HW, Al-Hasani, H	Biochim. Biophys. Acta	2005
9228007	Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B Stokoe, D, Stephens, LR, Copeland, T, Gaffney, PR, Reese, CB, Painter, GF, Holmes, AB, McCormick, F, Hawkins, PT	Science	1997
9094314	Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Alessi, DR, James, SR, Downes, CP, Holmes, AB, Gaffney, PR, Reese, CB, Cohen, P	Curr Biol	1997