Reactome | PDPK1 binds PIP3

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PDPK1 binds PIP3 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
dbId	109701
displayName	PDPK1 binds PIP3
eventOf	[Pathway:R-HSA-165158] Activation of AKT2 - Homo sapiens
followingEvent	[Reaction:R-HSA-109702] PDPK1 phosphorylates AKT2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-61459] PDPK1 [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2219518] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 [LiteratureReference:8984042] Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	PDPK1 binds PIP3
orthologousEvent	[Reaction:R-MMU-109701] PDPK1 binds PIP3 - Mus musculus [Reaction:R-PFA-109701] PDPK1 binds PIP3 - Plasmodium falciparum [Reaction:R-SCE-109701] PDPK1 binds PIP3 - Saccharomyces cerevisiae [Reaction:R-SPO-109701] PDPK1 binds PIP3 - Schizosaccharomyces pombe [Reaction:R-DDI-109701] PDPK1 binds PIP3 - Dictyostelium discoideum [Reaction:R-CEL-109701] PDPK1 binds PIP3 - Caenorhabditis elegans [Reaction:R-DME-109701] PDPK1 binds PIP3 - Drosophila melanogaster [Reaction:R-GGA-109701] PDPK1 binds PIP3 - Gallus gallus [Reaction:R-XTR-109701] PDPK1 binds PIP3 - Xenopus tropicalis [Reaction:R-DRE-109701] PDPK1 binds PIP3 - Danio rerio [Reaction:R-SSC-109701] PDPK1 binds PIP3 - Sus scrofa [Reaction:R-BTA-109701] PDPK1 binds PIP3 - Bos taurus [Reaction:R-CFA-109701] PDPK1 binds PIP3 - Canis familiaris [Reaction:R-RNO-109701] PDPK1 binds PIP3 - Rattus norvegicus
output	[Complex:R-HSA-109697] PDPK1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109701
summation	[Summation:179030] PIP3 generated by PI3K recruits phosphatidylinositide-depend...

Referrals

(hasEvent)	[Pathway:R-HSA-165158] Activation of AKT2
(precedingEvent)	[Reaction:R-HSA-109702] PDPK1 phosphorylates AKT2