Reactome | ep300 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

ep300 [nucleoplasm] Show undefined attributes

candidateOf	[CandidateSet:R-XTR-9620507] KAT2B,(EP300) [nucleoplasm] - Xenopus tropicalis
catalystActivities	[CatalystActivity:10722802] protein-lysine-acetyltransferase activity of EP300 [nucleoplasm] [CatalystActivity:10693855] histone acetyltransferase activity of EP300 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-9926393] MITF-M:CREBBP,EP300 [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-9008268] ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-9018479] TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-1604462] NOTCH1 Coactivator Complex [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-9023842] CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 - Xenopus tropicalis [Reaction:R-XTR-9926478] MITF-M binds CREBBP,EP300 - Xenopus tropicalis [Reaction:R-XTR-8951951] RUNX3 binds EP300 - Xenopus tropicalis [Reaction:R-XTR-8878056] RUNX1:CBFB binds EP300 - Xenopus tropicalis [Reaction:R-XTR-3222093] BRD7 binds TP53 and EP300 - Xenopus tropicalis [Reaction:R-XTR-6811479] ING2 recruits EP300 to TP53 - Xenopus tropicalis [Reaction:R-XTR-9760082] NFE2L2 binds CREBBP,EP300 - Xenopus tropicalis [Reaction:R-XTR-3322427] Beta-catenin recruits CBP/p300 - Xenopus tropicalis [Reaction:R-XTR-933536] p-IRF7 dimer interacts with coactivator CBP/p300 - Xenopus tropicalis [Reaction:R-XTR-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter - Xenopus tropicalis [Reaction:R-XTR-9023840] HATs and coactivators are recruited to the CTSD gene - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10678646
displayName	ep300 [nucleoplasm]
endCoordinate	2414
inDisease	false
inferredFrom	[DefinedSet:R-HSA-1027362] CREBBP,EP300 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-XTR-9023862] histone acetyltransferases [nucleoplasm] - Xenopus tropicalis
name	ep300 EP300 F7DX95
negativelyRegulates	[NegativeRegulation:10717895] Negative regulation by 'EP300 [nucleoplasm]'
producedByEvent	[Reaction:R-XTR-8952058] CCND1 binds RUNX3 and displaces EP300 - Xenopus tropicalis
referenceEntity	[ReferenceGeneProduct:uniprot:F7DX95] UniProt:F7DX95
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-381325
startCoordinate	2

Referrals

(hasMember)	[DefinedSet:R-XTR-9023862] histone acetyltransferases [nucleoplasm]
(input)	[Reaction:R-XTR-9023840] HATs and coactivators are recruited to the CTSD gene [Reaction:R-XTR-9008285] NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 [Reaction:R-XTR-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter [Reaction:R-XTR-9926478] MITF-M binds CREBBP,EP300 [Reaction:R-XTR-8951951] RUNX3 binds EP300 [Reaction:R-XTR-8878056] RUNX1:CBFB binds EP300 [Reaction:R-XTR-3222093] BRD7 binds TP53 and EP300 [Reaction:R-XTR-6811479] ING2 recruits EP300 to TP53 [Reaction:R-XTR-9760082] NFE2L2 binds CREBBP,EP300 [Reaction:R-XTR-3322427] Beta-catenin recruits CBP/p300 [Reaction:R-XTR-933536] p-IRF7 dimer interacts with coactivator CBP/p300
(hasComponent)	[Complex:R-XTR-9023842] CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] [Complex:R-XTR-9008268] ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] [Complex:R-XTR-9018479] TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] [Complex:R-XTR-8869505] MYSM1:EP300:KAT2B [nucleoplasm] [Complex:R-XTR-9926393] MITF-M:CREBBP,EP300 [nucleoplasm] [Complex:R-XTR-8951952] RUNX3:CBFB:EP300 [nucleoplasm] [Complex:R-XTR-8951959] Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] [Complex:R-XTR-8878064] RUNX1:CBFB:EP300 [nucleoplasm] [Complex:R-XTR-8936477] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] [Complex:R-XTR-5628870] BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] [Complex:R-XTR-3222096] BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] [Complex:R-XTR-6811488] ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] [Complex:R-XTR-3215194] ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] [Complex:R-XTR-9760065] p-NFE2L2:CREBBP,EP300 [nucleoplasm] [Complex:R-XTR-9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] [Complex:R-XTR-3322396] TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] [Complex:R-XTR-933471] CBP/p300:pIRF7:pIRF7 [nucleoplasm] [Complex:R-XTR-1604462] NOTCH1 Coactivator Complex [nucleoplasm]
(physicalEntity)	[CatalystActivity:10722802] protein-lysine-acetyltransferase activity of EP300 [nucleoplasm] [CatalystActivity:10693855] histone acetyltransferase activity of EP300 [nucleoplasm]
(activeUnit)	[CatalystActivity:10724036] protein N-acetyltransferase activity of p-NFE2L2:CREBBP,EP300 [nucleoplasm] [CatalystActivity:10699824] acetyltransferase activity of BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] [CatalystActivity:10711149] protein-lysine-acetyltransferase activity of ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm]
(hasCandidate)	[CandidateSet:R-XTR-9620507] KAT2B,(EP300) [nucleoplasm]
(regulator)	[NegativeRegulation:10717895] Negative regulation by 'EP300 [nucleoplasm]'
(output)	[Reaction:R-XTR-8952058] CCND1 binds RUNX3 and displaces EP300
(inferredTo)	[DefinedSet:R-HSA-1027362] CREBBP,EP300 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm]

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