Reactome | MITF-M binds CREBBP,EP300

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MITF-M binds CREBBP,EP300 Show undefined attributes

authored	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9926473] Rothfels, Karen, 2024-11-01
dbId	9926478
displayName	MITF-M binds CREBBP,EP300
edited	[InstanceEdit:9927257] Rothfels, Karen, 2024-11-05
eventOf	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity - Homo sapiens
followingEvent	[Reaction:R-HSA-9926482] CREBBP, EP300 acetylate MITF-M - Homo sapiens
input	[DefinedSet:R-HSA-1027362] CREBBP,EP300 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9824664] MITF-M [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9824925] CBP/p300 as a co-factor for the Microphthalmia transcription factor [LiteratureReference:9926285] The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300 [LiteratureReference:9926257] Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor [LiteratureReference:9824931] Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia [LiteratureReference:9824946] c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MITF-M binds CREBBP,EP300
orthologousEvent	[Reaction:R-CEL-9926478] MITF-M binds CREBBP,EP300 - Caenorhabditis elegans [Reaction:R-DME-9926478] MITF-M binds CREBBP,EP300 - Drosophila melanogaster [Reaction:R-GGA-9926478] MITF-M binds CREBBP,EP300 - Gallus gallus [Reaction:R-XTR-9926478] MITF-M binds CREBBP,EP300 - Xenopus tropicalis [Reaction:R-SSC-9926478] MITF-M binds CREBBP,EP300 - Sus scrofa [Reaction:R-BTA-9926478] MITF-M binds CREBBP,EP300 - Bos taurus [Reaction:R-CFA-9926478] MITF-M binds CREBBP,EP300 - Canis familiaris [Reaction:R-RNO-9926478] MITF-M binds CREBBP,EP300 - Rattus norvegicus [Reaction:R-MMU-9926478] MITF-M binds CREBBP,EP300 - Mus musculus
output	[Complex:R-HSA-9926393] MITF-M:CREBBP,EP300 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9730412] MITF gene expression - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9926478
summation	[Summation:9926305] MITF-M interacts with CREBBP and EP300 to activate expressio...

Referrals

(hasEvent)	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity
(precedingEvent)	[Reaction:R-HSA-9926482] CREBBP, EP300 acetylate MITF-M