Reactome | MyD88:TIRAP-dependent cascade initiated on plasma membrane

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MyD88:TIRAP-dependent cascade initiated on plasma membrane Show undefined attributes

authored	[InstanceEdit:451592] Shamovsky, V, 2010-01-05
created	[InstanceEdit:451501] Shamovsky, V, 2010-01-05
dbId	451514
displayName	MyD88:TIRAP-dependent cascade initiated on plasma membrane
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-517856] TLR2 subfamily cascade - Gallus gallus [Pathway:R-GGA-433794] TLR4 cascade - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:259820] MyD88-dependent toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-433961] Activated TLR homo- or heterodimer recruits adaptors TIRAP(or MAL) and MyD88 - Gallus gallus [Reaction:R-GGA-434073] IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 - Gallus gallus [Reaction:R-GGA-434018] Autophosphorylation of chicken IRAK4 - Gallus gallus [Reaction:R-GGA-433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - Gallus gallus [Reaction:R-GGA-434047] phosphorylation of IRAK2 by activated IRAK4 - Gallus gallus [Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6 - Gallus gallus
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:571177] Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88) [LiteratureReference:573281] Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum [LiteratureReference:571257] Gene expression profiling of chicken lymphoid cells after treatment with Lactobacillus acidophilus cellular components [LiteratureReference:573284] Toll-like receptors: lessons from knockout mice
maxDepth	5
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	MyD88:TIRAP-dependent cascade initiated on plasma membrane
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-451514
summation	[Summation:573260] Myeloid differentiation factor 88 (MyD88) is Toll/interleuki...
updateTrackers	[UpdateTracker:9789908] Update Tracker - [Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - v36:[modifyText, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774915] Update Tracker - [Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - v80:[updateContainedPathway] [UpdateTracker:9788199] Update Tracker - [Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - v43:[updateContainedPathway, updateIndirectRLE]

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[UpdateTracker:9789908] Update Tracker - [Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - v36:[modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9774915] Update Tracker - [Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - v80:[updateContainedPathway]
[UpdateTracker:9788199] Update Tracker - [Pathway:451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - v43:[updateContainedPathway, updateIndirectRLE]

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