Reactome | NFkB and MAPK activation mediated by TRAF6

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authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	433822
displayName	NFkB and MAPK activation mediated by TRAF6
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - Gallus gallus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-434053] TRAF6 binds to p-IRAK2 complexed with activated TLR - Gallus gallus [Reaction:R-GGA-434084] p-IRAK2- TRAF6 dissociates from the activated chTLR complex - Gallus gallus [Reaction:R-GGA-451466] TRAF6 binding to activated IRAK2 stimulates its oligomerization - Gallus gallus [BlackBoxEvent:R-GGA-451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - Gallus gallus [BlackBoxEvent:R-GGA-451470] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 - Gallus gallus [Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex - Gallus gallus [Reaction:R-GGA-451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 - Gallus gallus [Pathway:R-GGA-434001] TAK1 activates NFkB by phosphorylation and activation of IKKs complex - Gallus gallus [Pathway:R-GGA-451524] MAPK activation in TLR cascade - Gallus gallus
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:571255] Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways [LiteratureReference:517851] Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1
maxDepth	4
modified	[InstanceEdit:9856140] Shamovsky, Veronica, 2023-12-11
name	NFkB and MAPK activation mediated by TRAF6
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-433822
summation	[Summation:573278] Treatment of chicken heterophiles with either flagellin or l...
updateTrackers	[UpdateTracker:9789906] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v36:[updateContainedRLE] [UpdateTracker:9775187] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v80:[updateContainedPathway] [UpdateTracker:9778390] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v68:[updateContainedPathway] [UpdateTracker:9788171] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v43:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774654] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v81:[updateIndirectRLE]

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[UpdateTracker:9789906] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v36:[updateContainedRLE]
[UpdateTracker:9775187] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v80:[updateContainedPathway]
[UpdateTracker:9778390] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v68:[updateContainedPathway]
[UpdateTracker:9788171] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v43:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9774654] Update Tracker - [Pathway:433822] NFkB and MAPK activation mediated by TRAF6 - v81:[updateIndirectRLE]

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