Reactome | TLR4 cascade

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TLR4 cascade Show undefined attributes

authored	[InstanceEdit:749442] Shamovsky, V, 2010-05-18
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	433794
displayName	TLR4 cascade
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-437987] Toll-like receptors (TLR) cascades - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:259012] toll-like receptor 4 signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-433940] Association of LBP with bacterial LPS - Gallus gallus [Reaction:R-GGA-434003] LPS binding to CD14 co-receptor - Gallus gallus [Reaction:R-GGA-434058] LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96 - Gallus gallus [Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - Gallus gallus
isInDisease	false
isInferred	false
lastUpdatedDate	2019-12-10
literatureReference	[LiteratureReference:573281] Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum [LiteratureReference:433799] Lipopolysaccharide binding protein/CD14/ TLR4-dependent recognition of salmonella LPS induces the functional activation of chicken heterophils and up-regulation of pro-inflammatory cytokine and chemokine gene expression in these cells
maxDepth	6
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	TLR4 cascade
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-433794
summation	[Summation:975749] Toll-like Receptor 4 is an evolutionarily conserved microbe ...
updateTrackers	[UpdateTracker:9777501] Update Tracker - [Pathway:433794] TLR4 cascade - v71:[addHasEvent] [UpdateTracker:9789905] Update Tracker - [Pathway:433794] TLR4 cascade - v36:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9785410] Update Tracker - [Pathway:433794] TLR4 cascade - v52:[updateContainedRLE] [UpdateTracker:9777959] Update Tracker - [Pathway:433794] TLR4 cascade - v68:[removeHasEvent]

Referrals

(updatedInstance)

[UpdateTracker:9777501] Update Tracker - [Pathway:433794] TLR4 cascade - v71:[addHasEvent]
[UpdateTracker:9789905] Update Tracker - [Pathway:433794] TLR4 cascade - v36:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9785410] Update Tracker - [Pathway:433794] TLR4 cascade - v52:[updateContainedRLE]
[UpdateTracker:9777959] Update Tracker - [Pathway:433794] TLR4 cascade - v68:[removeHasEvent]

(hasEvent)

[Pathway:R-GGA-437987] Toll-like receptors (TLR) cascades

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