Reactome | IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88

Schema > Reaction > Entries

IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 Show undefined attributes

authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	433864
displayName	IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - Gallus gallus
followingEvent	[Reaction:R-GGA-434047] phosphorylation of IRAK2 by activated IRAK4 - Gallus gallus
inferredFrom	[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - Homo sapiens
input	[Complex:R-GGA-434022] activated TLR : TIRAP : MyD88 ; p-IRAK4 [plasma membrane] 2 × [EntityWithAccessionedSequence:R-GGA-434068] IRAK2 [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:434579] The avian Toll-Like receptor pathway--subtle differences amidst general conformity [LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
output	[Complex:R-GGA-434002] IRAK2 : p-IRAK4 :MyD88 : TIRAP : activated TLR [plasma membrane]
precedingEvent	[Reaction:R-GGA-434018] Autophosphorylation of chicken IRAK4 - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-433864
summation	[Summation:570878] In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...
updateTrackers	[UpdateTracker:9789925] Update Tracker - [Reaction:433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - v36:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789925] Update Tracker - [Reaction:433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - v36:[modifyText]
(hasEvent)	[Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-GGA-434047] phosphorylation of IRAK2 by activated IRAK4
(inferredTo)	[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex

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