MyD88:TIRAP-dependent cascade initiated on plasma membrane

Stable Identifier
R-GGA-451514
Type
Pathway
Species
Gallus gallus
Related Species
Salmonella typhimurium
ReviewStatus
5/5
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MyD88:TIRAP-dependent cascade initiated on plasma membrane
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Myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays a crucial role in TLR signaling. All TLRs except TLR3 can initiate downstream signaling through MyD88. In the MyD88-dependent pathway, once the adaptor is bound to TLR it leads to recruitment of proteins of the IL1 receptor associated kinase family - IRAK, followed by activation of tumor necrosis factor receptor-associated factor 6 (TRAF6). TRAF6 is an ubiquitin E3 ligase which in turn induces autophosphorylation of TGF-beta activating kinase 1 (TAK1). Activated TAK1 can ultimately mediate the induction of transcription factor NF-kB or mitogen-activated protein kinases (MAPK), such as JNK, p38 and ERK. This results in the translocation of the activated NF-kB and MAPKs to the nucleus and the initiation of appropriate gene transcription leading to the production of many proinflammatory cytokines and antimicrobial peptides.

The chicken MyD88 gene was cloned and its expression was detected in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus and bursa. Over-expression of chicken MyD88 (299aa) significantly stimulated the activation of NF-kB in vitro.

Literature References
PubMed ID Title Journal Year
11044373 Toll-like receptors: lessons from knockout mice

Akira, S

Biochem Soc Trans 2000
20053507 Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum

Li, P, Xia, P, Wen, J, Zheng, M, Chen, J, Zhao, J, Jiang, R, Liu, R, Zhao, G

Vet Microbiol 2009
17981327 Gene expression profiling of chicken lymphoid cells after treatment with Lactobacillus acidophilus cellular components

Brisbin, JT, Zhou, H, Gong, J, Sabour, P, Akbari, MR, Haghighi, HR, Yu, H, Clarke, A, Sarson, AJ, Sharif, S

Dev Comp Immunol 2008
18582498 Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88)

Qiu, Y, Shen, Y, Li, X, Ding, C, Ma, Z

Dev Comp Immunol 2008
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Go Biological Process
MyD88-dependent toll-like receptor signaling pathway (0002755)
Authored
Shamovsky, V  (2010-01-05)
Reviewed
D'Eustachio, P  (2010-10-16)
Created
Shamovsky, V  (2010-01-05)
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