Reactome | Autophosphorylation of chicken IRAK4

Schema > Reaction > Entries

Autophosphorylation of chicken IRAK4 Show undefined attributes

authored	[InstanceEdit:434153] Shamovsky, V, 2009-08-26
catalystActivity	[CatalystActivity:433896] protein serine/threonine kinase activity of activated TLR homo- or heterodimer : TIRAP :MyD88 :IRAK4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:434122] Shamovsky, V, 2009-08-26
dbId	434018
displayName	Autophosphorylation of chicken IRAK4
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane - Gallus gallus
followingEvent	[Reaction:R-GGA-433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - Gallus gallus
inferredFrom	[Reaction:R-HSA-937022] IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP - Homo sapiens
input	[Complex:R-GGA-433831] activated TLR homo- or heterodimer : TIRAP :MyD88 :IRAK4 [plasma membrane] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of chicken IRAK4
output	[Complex:R-GGA-434022] activated TLR : TIRAP : MyD88 ; p-IRAK4 [plasma membrane] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-GGA-434073] IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-434018
summation	[Summation:570886] Chicken IRAK4 shows 66% amino acid identity to human IRAK4. ...

Referrals

(precedingEvent)	[Reaction:R-GGA-433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88
(hasEvent)	[Pathway:R-GGA-451514] MyD88:TIRAP-dependent cascade initiated on plasma membrane
(inferredTo)	[Reaction:R-HSA-937022] IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP