Reactome | Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb

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Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 Show undefined attributes

authored	[InstanceEdit:451590] Shamovsky, V, 2010-01-05
catalystActivity	[CatalystActivity:451446] ubiquitin-protein transferase activity of oligo TRAF6 : p-IRAK2 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:451437] Shamovsky, V, 2010-01-05
dbId	451470
displayName	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6 - Gallus gallus
followingEvent	[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:436928] free ubiquitin chain polymerization
inferredFrom	[Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Homo sapiens
input	3 × [DefinedSet:R-GGA-434147] Ubiquitin [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK [LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:444058] Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling [LiteratureReference:451472] TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6
output	[Polymer:R-GGA-451962] free K63_polyubiquitin chain [cytosol]
precedingEvent	[BlackBoxEvent:R-GGA-451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - Gallus gallus
releaseDate	2010-12-14
requiredInputComponent	[Complex:R-GGA-433960] UBE2N : UBE2V complex [cytosol] - Gallus gallus
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-451470
summation	[Summation:446233] TRAF6 generates unanchored Lys63-linked polyubiquitin chains...

Referrals

(hasEvent)	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6
(precedingEvent)	[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex
(inferredTo)	[Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains

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