Reactome | TRAF6 binding to activated IRAK2 stimulates its oligomerization

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TRAF6 binding to activated IRAK2 stimulates its oligomerization Show undefined attributes

authored	[InstanceEdit:451587] Shamovsky, V, 2010-01-05
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:451437] Shamovsky, V, 2010-01-05
dbId	451466
displayName	TRAF6 binding to activated IRAK2 stimulates its oligomerization
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6 - Gallus gallus
followingEvent	[BlackBoxEvent:R-GGA-451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-936963] IRAK2 induces TRAF6 oligomerization - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-GGA-433886] TRAF6 [cytosol] [Complex:R-GGA-433829] TRAF6:p-IRAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:450115] TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 binding to activated IRAK2 stimulates its oligomerization
output	[Complex:R-GGA-451475] oligo TRAF6 : p-IRAK2 [plasma membrane]
precedingEvent	[Reaction:R-GGA-434084] p-IRAK2- TRAF6 dissociates from the activated chTLR complex - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-451466
summation	[Summation:571290] There is little experimental data about mammalian IRAK2 medi...
updateTrackers	[UpdateTracker:9789978] Update Tracker - [Reaction:451466] TRAF6 binding to activated IRAK2 stimulates its oligomerization - v36:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789978] Update Tracker - [Reaction:451466] TRAF6 binding to activated IRAK2 stimulates its oligomerization - v36:[modifyText]
(hasEvent)	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6
(precedingEvent)	[BlackBoxEvent:R-GGA-451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2
(inferredTo)	[Reaction:R-HSA-936963] IRAK2 induces TRAF6 oligomerization

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