Reactome | Auto ubiquitination of oligo TRAF6 bound to p-IRAK2

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Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 Show undefined attributes

authored	[InstanceEdit:451580] Shamovsky, V, 2010-01-05
catalystActivity	[CatalystActivity:451446] ubiquitin-protein transferase activity of oligo TRAF6 : p-IRAK2 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:451437] Shamovsky, V, 2010-01-05
dbId	451450
displayName	Auto ubiquitination of oligo TRAF6 bound to p-IRAK2
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6 - Gallus gallus
followingEvent	[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex - Gallus gallus [BlackBoxEvent:R-GGA-451470] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 - Gallus gallus
inferredFrom	[Reaction:R-HSA-202453] Auto-ubiquitination of TRAF6 - Homo sapiens
input	[Complex:R-GGA-451475] oligo TRAF6 : p-IRAK2 [plasma membrane] 9 × [DefinedSet:R-GGA-434147] Ubiquitin [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Auto ubiquitination of oligo TRAF6 bound to p-IRAK2
output	[Complex:R-GGA-451453] pUb oligo TRAF6 : p-IRAK2 [plasma membrane]
precedingEvent	[Reaction:R-GGA-451466] TRAF6 binding to activated IRAK2 stimulates its oligomerization - Gallus gallus
releaseDate	2010-12-14
requiredInputComponent	[Complex:R-GGA-433960] UBE2N : UBE2V complex [cytosol] - Gallus gallus
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-451450
summation	[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
updateTrackers	[UpdateTracker:9788119] Update Tracker - [BlackBoxEvent:451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - v43:[modifyText] [UpdateTracker:9789950] Update Tracker - [BlackBoxEvent:451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - v36:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788119] Update Tracker - [BlackBoxEvent:451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - v43:[modifyText] [UpdateTracker:9789950] Update Tracker - [BlackBoxEvent:451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - v36:[modifyText]
(hasEvent)	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6
(precedingEvent)	[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex [BlackBoxEvent:R-GGA-451470] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6
(inferredTo)	[Reaction:R-HSA-202453] Auto-ubiquitination of TRAF6