Reactome | pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex

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pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex Show undefined attributes

authored	[InstanceEdit:451589] Shamovsky, V, 2010-01-05
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:451437] Shamovsky, V, 2010-01-05
dbId	451463
displayName	pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex
edited	[InstanceEdit:994006] Shamovsky, V, 2010-11-05
eventOf	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6 - Gallus gallus
followingEvent	[Reaction:R-GGA-451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Homo sapiens
input	2 × [Polymer:R-GGA-451962] free K63_polyubiquitin chain [cytosol] [Complex:R-GGA-451453] pUb oligo TRAF6 : p-IRAK2 [plasma membrane] 2 × [Complex:R-GGA-433839] TAK1 : TAB1 : TAB2/TAB3 complex [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex
output	[Complex:R-GGA-434148] p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane]
precedingEvent	[BlackBoxEvent:R-GGA-451450] Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 - Gallus gallus [BlackBoxEvent:R-GGA-451470] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:977269] D'Eustachio, P, 2010-10-15
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-451463
summation	[Summation:434094] Polyubiquitinated TRAF6 activates TAK1 by binding to the ubi...

Referrals

(hasEvent)	[Pathway:R-GGA-433822] NFkB and MAPK activation mediated by TRAF6
(precedingEvent)	[Reaction:R-GGA-451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1
(inferredTo)	[Reaction:R-HSA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex

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