Reactome | Interleukin-35 Signalling

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Interleukin-35 Signalling Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444702
displayName	Interleukin-35 Signalling
eventOf	[Pathway:R-BTA-447115] Interleukin-12 family signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:436403] interleukin-35-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-BTA-8950362] EBI3:CANX binds IL12A - Bos taurus [BlackBoxEvent:R-BTA-8950740] CANX dissociates from IL12A:EBI3 - Bos taurus [BlackBoxEvent:R-BTA-448627] Interleukin-35 translocates from the ER lumen to the extracellular region - Bos taurus [BlackBoxEvent:R-BTA-8984001] IL35 binds IL27RA:IL12RB2 receptor - Bos taurus [BlackBoxEvent:R-BTA-8984012] JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated - Bos taurus [BlackBoxEvent:R-BTA-8984021] STAT1,STAT3 associate with IL27RA:IL12RB2 receptor - Bos taurus [BlackBoxEvent:R-BTA-8984014] JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 - Bos taurus [BlackBoxEvent:R-BTA-8984023] p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor - Bos taurus [BlackBoxEvent:R-BTA-8983519] IL35 binds IL12RB2:IL12RB2 receptor - Bos taurus [BlackBoxEvent:R-BTA-8983870] JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated - Bos taurus [BlackBoxEvent:R-BTA-8983876] STAT4 binds IL12RB2:IL12RB2 - Bos taurus [BlackBoxEvent:R-BTA-8983872] JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 - Bos taurus [BlackBoxEvent:R-BTA-8983878] p-STAT4 dissociates from IL12RB2:IL12RB2 receptor - Bos taurus [BlackBoxEvent:R-BTA-8983518] IL35 binds IL6ST:IL6ST receptor - Bos taurus [BlackBoxEvent:R-BTA-8983834] JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated - Bos taurus [BlackBoxEvent:R-BTA-8983841] STAT1 associates with IL6ST:IL6ST - Bos taurus [BlackBoxEvent:R-BTA-8983835] JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 - Bos taurus [BlackBoxEvent:R-BTA-8983845] p-STAT1 dissociates from IL6ST:IL6ST - Bos taurus [BlackBoxEvent:R-BTA-6809140] IL35 binds IL-12RB2:IL6ST receptor - Bos taurus [BlackBoxEvent:R-BTA-8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated - Bos taurus [BlackBoxEvent:R-BTA-8983996] STAT1 and STAT4 associate with IL12RB2:IL6ST receptor - Bos taurus [BlackBoxEvent:R-BTA-8950453] JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 - Bos taurus [BlackBoxEvent:R-BTA-8983983] p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor - Bos taurus [BlackBoxEvent:R-BTA-8950522] p-STAT1:p-STAT4 translocates to the nucleus - Bos taurus
inferredFrom	[Pathway:R-HSA-8984722] Interleukin-35 Signalling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-35 Signalling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-8984722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-447115] Interleukin-12 family signaling
(inferredTo)	[Pathway:R-HSA-8984722] Interleukin-35 Signalling

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