Reactome | IL35 binds IL-12RB2:IL6ST receptor

Schema > BlackBoxEvent > Entries

IL35 binds IL-12RB2:IL6ST receptor Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10417306
displayName	IL35 binds IL-12RB2:IL6ST receptor
eventOf	[Pathway:R-BTA-8984722] Interleukin-35 Signalling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor - Homo sapiens
input	[Complex:R-BTA-8950039] IL12RB2:JAK2 [plasma membrane] [Complex:R-BTA-622267] IL35 [extracellular region] [Complex:R-BTA-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL35 binds IL-12RB2:IL6ST receptor Interleukin-35 binds Interleukin-35 receptor Interleukin-35 binds Interleukin-6 receptor beta:Interleukin 12 Receptor beta 2 complex
output	[Complex:R-BTA-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-448627] Interleukin-35 translocates from the ER lumen to the extracellular region - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-6809140
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8984722] Interleukin-35 Signalling
(precedingEvent)	[BlackBoxEvent:R-BTA-8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
(inferredTo)	[BlackBoxEvent:R-HSA-6809140] IL35 binds IL-12RB2:IL6ST receptor

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