Reactome | JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated

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JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10429264
displayName	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
eventOf	[Pathway:R-BTA-8984722] Interleukin-35 Signalling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-8983876] STAT4 binds IL12RB2:IL12RB2 - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-8983870] JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-8983520] IL35:(IL12RB2:JAK2 dimer) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-8983873] IL35:(IL12RB2:p-JAK2) dimer [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-8983519] IL35 binds IL12RB2:IL12RB2 receptor - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-8983870
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8984722] Interleukin-35 Signalling
(precedingEvent)	[BlackBoxEvent:R-BTA-8983876] STAT4 binds IL12RB2:IL12RB2
(inferredTo)	[BlackBoxEvent:R-HSA-8983870] JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated

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