Reactome | JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated

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JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10429248
displayName	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
eventOf	[Pathway:R-BTA-8984722] Interleukin-35 Signalling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-8983841] STAT1 associates with IL6ST:IL6ST - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-8983834] JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-8983525] IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-8985441] IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane]
precedingEvent	[BlackBoxEvent:R-BTA-8983518] IL35 binds IL6ST:IL6ST receptor - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-8983834
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8984722] Interleukin-35 Signalling
(precedingEvent)	[BlackBoxEvent:R-BTA-8983841] STAT1 associates with IL6ST:IL6ST
(inferredTo)	[BlackBoxEvent:R-HSA-8983834] JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated

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