Reactome | CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6

Schema > Reaction > Entries

CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 Show undefined attributes

catalystActivity	[CatalystActivity:10345680] protein serine/threonine kinase activity of CAK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10426338
displayName	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
eventOf	[Pathway:R-BTA-69231] Cyclin D associated events in G1 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9754130] CDK4 inhibitors bind CDK4 - Bos taurus [Reaction:R-BTA-9754129] CDK6 inhibitors bind CDK6 - Bos taurus [Reaction:R-BTA-1226095] Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex - Bos taurus [Reaction:R-BTA-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex - Bos taurus [Reaction:R-BTA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Bos taurus
inferredFrom	[Reaction:R-HSA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-BTA-8949874] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-BTA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-BTA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8942836
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-69231] Cyclin D associated events in G1
(precedingEvent)	[Reaction:R-BTA-9754130] CDK4 inhibitors bind CDK4 [Reaction:R-BTA-9754129] CDK6 inhibitors bind CDK6 [Reaction:R-BTA-1226095] Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex [Reaction:R-BTA-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex [Reaction:R-BTA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
(inferredTo)	[Reaction:R-HSA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6