Reactome | Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex

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Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex Show undefined attributes

catalystActivity	[CatalystActivity:10333692] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10375206
displayName	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
eventOf	[Pathway:R-BTA-69231] Cyclin D associated events in G1 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1363276] Dephosphorylation of p130 (RBL2) by PP2A - Bos taurus [Reaction:R-BTA-1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex - Bos taurus
inferredFrom	[Reaction:R-HSA-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-BTA-1226089] RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-BTA-1226072] E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-1226084] phospho-p-T401,S672,S1035-RBL2 [nucleoplasm]
precedingEvent	[Reaction:R-BTA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1226094
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-69231] Cyclin D associated events in G1
(precedingEvent)	[Reaction:R-BTA-1363276] Dephosphorylation of p130 (RBL2) by PP2A [Reaction:R-BTA-1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
(inferredTo)	[Reaction:R-HSA-1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex

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