Reactome | p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]

Schema > CandidateSet > Entries

p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10333692] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10333691
displayName	p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
hasCandidate	[Complex:R-BTA-8949894] p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] - Bos taurus
hasMember	[Complex:R-BTA-8949895] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] - Bos taurus [DefinedSet:R-BTA-9756822] p-T177-CDK6:CCND [nucleoplasm] - Bos taurus [DefinedSet:R-BTA-9756821] p-T172-CDK4:CCND [nucleoplasm] - Bos taurus
inDisease	false
inferredFrom	[CandidateSet:R-HSA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] - Homo sapiens
maxDepth	5
name	p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B)
negativelyRegulates	[NegativeRegulation:10430669] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
producedByEvent	[Reaction:R-BTA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Bos taurus
schemaClass	CandidateSet
species	[Species:48898] Bos taurus
stId	R-BTA-8949896

Referrals

(regulator)	[NegativeRegulation:10430669] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
(physicalEntity)	[CatalystActivity:10333692] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
(output)	[Reaction:R-BTA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
(inferredTo)	[CandidateSet:R-HSA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]

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