Reactome | TKIs (ERBB2) [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-9665121] ERBB2 KD mutants bind TKIs - Homo sapiens
created	[InstanceEdit:9665130] Orlic-Milacic, Marija, 2019-10-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665127
disease	[Disease:1500689] cancer
displayName	TKIs (ERBB2) [cytosol]
hasMember	[ChemicalDrug:R-ALL-1216521] Lapatinib [cytosol] [ChemicalDrug:R-ALL-1216527] neratinib [cytosol] [ChemicalDrug:R-ALL-9649872] Osimertinib [cytosol] [ChemicalDrug:R-ALL-1220577] Afatinib [cytosol] [ChemicalDrug:R-ALL-9649879] AZ5104 [cytosol] [ChemicalDrug:R-ALL-9646810] Tesevatinib [cytosol] [DefinedSet:R-ALL-9665128] AEE788,CP-724714,Canertinib [cytosol] [ChemicalDrug:R-ALL-9649894] Sapitinib [cytosol] [ChemicalDrug:R-ALL-1169429] Gefitinib [cytosol]
inDisease	true
isOrdered	true
maxDepth	3
name	TKIs (ERBB2)
schemaClass	DefinedSet
stId	R-ALL-9665127

(input)	[Reaction:R-HSA-9665121] ERBB2 KD mutants bind TKIs
(activeUnit)	[NegativeRegulation:9665329] Negative regulation by 'ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane]'

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