Reactome | Sapitinib [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9665140] ERBB2 KD mutants:sapitinib [plasma membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9665304] ERBB2 T862A does not bind sapitinib - Homo sapiens
created	[InstanceEdit:9649892] Orlic-Milacic, Marija, 2019-06-17
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:9717767] ChEBI:132986
dbId	9649894
disease	[Disease:1500689] cancer
displayName	Sapitinib [cytosol]
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol]
modified	[InstanceEdit:9717734] Stephan, Ralf, 2021-03-15
name	Sapitinib
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:7717] sapitinib [Guide to Pharmacology:7717]
schemaClass	ChemicalDrug
stId	R-ALL-9649894

(input)	[FailedReaction:R-HSA-9665304] ERBB2 T862A does not bind sapitinib
(hasComponent)	[Complex:R-HSA-9665140] ERBB2 KD mutants:sapitinib [plasma membrane]
(hasMember)	[DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol] [DefinedSet:R-ALL-9652360] lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]

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