Reactome | neratinib [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9665146] ERBB2 KD mutants:neratinib [plasma membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9665286] Resistant ERBB2 KD mutants do not bind neratinib - Homo sapiens
created	[InstanceEdit:1216529] Orlic-Milacic, Marija, 2011-02-15
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:9628025] ChEBI:61390
dbId	1216527
disease	[Disease:1500689] cancer
displayName	neratinib [cytosol]
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-ALL-1216531] Irreversible anti-EGFRplus TKIs [cytosol] [DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol] [DefinedSet:R-ALL-9652360] lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
modified	[InstanceEdit:9709260] Jassal, Bijay, 2020-12-11
name	neratinib HKI-272 Irreversible tyrosine kinase inhibitor HKI-272 generic inhibits EGFR and ERBB2 (HER2)
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:5686] neratinib [Guide to Pharmacology:5686]
schemaClass	ChemicalDrug
stId	R-ALL-1216527
updateTrackers	[UpdateTracker:9901076] Update Tracker - [ChemicalDrug:1216527] neratinib [cytosol] - v72:[removeName] [UpdateTracker:9901981] Update Tracker - [ChemicalDrug:1216527] neratinib [cytosol] - v76:[modifyName]

(updatedInstance)	[UpdateTracker:9901076] Update Tracker - [ChemicalDrug:1216527] neratinib [cytosol] - v72:[removeName] [UpdateTracker:9901981] Update Tracker - [ChemicalDrug:1216527] neratinib [cytosol] - v76:[modifyName]
(hasMember)	[DefinedSet:R-ALL-1216531] Irreversible anti-EGFRplus TKIs [cytosol] [DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol] [DefinedSet:R-HSA-1237431] afatinib, neratinib, lapatinib [cytosol] [DefinedSet:R-ALL-9652360] lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
(input)	[FailedReaction:R-HSA-9665286] Resistant ERBB2 KD mutants do not bind neratinib
(hasComponent)	[Complex:R-HSA-9665146] ERBB2 KD mutants:neratinib [plasma membrane] [Complex:R-HSA-9665942] ERBB2 TMD/JMD mutants (neratinib):neratinib [plasma membrane]