Reactome | Gefitinib [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9665139] ERBB2 L755_T759del:gefitinib [plasma membrane] - Homo sapiens
created	[InstanceEdit:1169430] Orlic-Milacic, Marija, 2011-01-18
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:9628106] ChEBI:49668
dbId	1169429
disease	[Disease:1500689] cancer
displayName	Gefitinib [cytosol]
inDisease	true
literatureReference	[LiteratureReference:1181162] ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy [LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
maxDepth	1
memberOf	[DefinedSet:R-ALL-1176053] Reversible EGFR-specific TKIs [cytosol] [DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol]
modified	[InstanceEdit:9631716] Wu, G, 2018-12-12
name	Gefitinib Iressa ZD1839 Reversible tyrosine kinase inhibitor gefitinib EGFR specific
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:4941] gefitinib [Guide to Pharmacology:4941]
schemaClass	ChemicalDrug
stId	R-ALL-1169429
summation	[Summation:1181169] Gefitinib (ZD1839, Iressa) is a low-molecular-weight EGFR ty...

(hasMember)	[DefinedSet:R-ALL-1176053] Reversible EGFR-specific TKIs [cytosol] [DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol]
(hasComponent)	[Complex:R-HSA-9665139] ERBB2 L755_T759del:gefitinib [plasma membrane]

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