Reactome | Afatinib [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9665137] ERBB2 KD mutants:afatinib [plasma membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9665311] ERBB2 T798M does not bind afatinib - Homo sapiens
created	[InstanceEdit:1220584] Orlic-Milacic, Marija, 2011-02-22
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:9628025] ChEBI:61390
dbId	1220577
disease	[Disease:1500689] cancer
displayName	Afatinib [cytosol]
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-HSA-1237431] afatinib, neratinib, lapatinib [cytosol] - Homo sapiens [DefinedSet:R-ALL-1216531] Irreversible anti-EGFRplus TKIs [cytosol] [DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol]
modified	[InstanceEdit:9631716] Wu, G, 2018-12-12
name	Afatinib BIBW2992 Irreversible TKI inhibitor afatinib generic inhibits EGFR and ERBB2 (HER2)
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:5667] afatinib [Guide to Pharmacology:5667]
schemaClass	ChemicalDrug
stId	R-ALL-1220577

(hasMember)	[DefinedSet:R-ALL-1216531] Irreversible anti-EGFRplus TKIs [cytosol] [DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol] [DefinedSet:R-HSA-1237431] afatinib, neratinib, lapatinib [cytosol] [DefinedSet:R-ALL-9652360] lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
(input)	[FailedReaction:R-HSA-9665311] ERBB2 T798M does not bind afatinib
(hasComponent)	[Complex:R-HSA-9665137] ERBB2 KD mutants:afatinib [plasma membrane] [Complex:R-HSA-9665941] ERBB2 TMD/JMD mutants (afatinib):afatinib [plasma membrane]

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