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What is Reactome ?
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Karen Rothfels
ORCID
https://orcid.org/0000-0002-0705-7048
Are you Karen Rothfels ? Register or Connect your ORCID
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Expand All
Authored Pathways (15/216)
Date
Identifier
Pathway
Reference
2021-10-08
R-HSA-9755511
KEAP1-NFE2L2 pathway
BibTex
2021-10-08
R-HSA-9759194
Nuclear events mediated by NFE2L2
BibTex
2021-10-08
R-HSA-9762114
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
BibTex
2021-03-30
R-HSA-9701898
STAT3 nuclear events downstream of ALK signaling
BibTex
2021-03-30
R-HSA-9725370
Signaling by ALK fusions and activated point mutants
BibTex
2021-03-30
R-HSA-9725371
Nuclear events stimulated by ALK signaling in cancer
BibTex
2021-03-22
R-HSA-9700206
Signaling by ALK in cancer
BibTex
2021-03-22
R-HSA-9700645
ALK mutants bind TKIs
BibTex
2021-03-22
R-HSA-9700649
Drug resistance of ALK mutants
BibTex
2021-03-22
R-HSA-9717316
alectinib-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717301
NVP-TAE684-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717319
brigatinib-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717264
ASP-3026-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717329
lorlatinib-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717326
crizotinib-resistant ALK mutants
BibTex
Show all authored pathways...
Authored Reactions (15/1,351)
Date
Identifier
Reaction
Reference
2022-02-23
R-HSA-9755304
MUL1 ubiquitinates UBXN7
BibTex
2022-02-23
R-HSA-9755306
ub UBXN7 is degraded by the 26S proteasome
BibTex
2022-01-16
R-HSA-9755303
26S proteasome degrades HIFalpha
BibTex
2021-10-08
R-HSA-9759189
NFE2L2-dependent PRDX1 gene expression
BibTex
2021-10-08
R-HSA-9759129
NFE2L2 binds the PRDX1 promoter
BibTex
2021-10-08
R-HSA-9762100
MYC- and NICD1-dependent NFE2L2 gene expression
BibTex
2021-10-08
R-HSA-9762102
NICD1 binds the NFE2L2 promoter
BibTex
2021-10-08
R-HSA-9762097
MYC binds the NFE2L2 promoter
BibTex
2021-10-08
R-HSA-9760094
SRXN1 reduces hyperoxidized PRDX1 dimer
BibTex
2021-10-08
R-HSA-9759358
NFE2L2-dependent SRXN1 gene expression
BibTex
2021-10-08
R-HSA-9759334
NFE2L2 binds the SRXN1 gene
BibTex
2021-10-08
R-HSA-9766645
CUL3:RBX1 ubiquitinates KEAP1
BibTex
2021-10-08
R-HSA-9766687
SESN1,SESN1 bind SQSTM1 and KEAP1
BibTex
2021-10-08
R-HSA-9759172
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
BibTex
2021-10-08
R-HSA-9759169
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
BibTex
Show all authored reactions...
Reviewed Pathways (1/1)
Date
Identifier
Pathway
Reference
2016-09-17
R-HSA-3371497
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
BibTex
Show all reviewed pathways...
Reviewed Reactions (15/15)
Date
Identifier
Reaction
Reference
2016-09-17
R-HSA-5618099
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-5618110
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein
BibTex
2016-09-17
R-HSA-5618085
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein
BibTex
2016-09-17
R-HSA-5618107
ATP binding to HSP90 triggers conformation change
BibTex
2016-09-17
R-HSA-3371503
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
BibTex
2016-09-17
R-HSA-3371422
ATP hydrolysis by HSP70
BibTex
2016-09-17
R-HSA-3371590
HSP70 binds to HSP40:nascent protein
BibTex
2016-09-17
R-HSA-5618073
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
BibTex
2016-09-17
R-HSA-5618098
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
BibTex
2016-09-17
R-HSA-5618105
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein
BibTex
2016-09-17
R-HSA-9725885
P4 bind PGR (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-9705925
Androgens binds AR (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-9690534
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-5618080
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus
BibTex
2016-09-17
R-HSA-5618093
ATP hydrolysis by HSP90
BibTex
Show all reviewed reactions...
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