Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/229)
Date Identifier Pathway Reference
2023-12-21 R-HSA-9856651 MITF-M-dependent gene expression BibTex
2023-12-21 R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy BibTex
2023-12-21 R-HSA-9854909 Regulation of MITF-M dependent genes involved in invasion BibTex
2023-12-21 R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism BibTex
2023-12-21 R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity BibTex
2023-10-14 R-HSA-9842640 Signaling by LTK in cancer BibTex
2023-10-14 R-HSA-9842663 Signaling by LTK BibTex
2023-10-14 R-HSA-9851151 MDK and PTN in ALK signaling BibTex
2023-01-26 R-HSA-9730414 MITF-M-regulated melanocyte development BibTex
2023-01-26 R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation BibTex
2023-01-26 R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence BibTex
2023-01-26 R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis BibTex
2023-01-26 R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation BibTex
2021-10-08 R-HSA-9755511 KEAP1-NFE2L2 pathway BibTex
2021-10-08 R-HSA-9759194 Nuclear events mediated by NFE2L2 BibTex
Authored Reactions (15/1,519)
Date Identifier Reaction Reference
2024-03-01 R-HSA-9907145 IRF4 binds the TYR gene BibTex
2024-03-01 R-HSA-9907147 MITF-M-dependent IRF4 gene expression BibTex
2024-03-01 R-HSA-9907144 MITF-M dimer and TFAP2A bind the IRF4 gene BibTex
2024-03-01 R-HSA-9768533 SNAI2 binds CDH1 gene promoter BibTex
2023-12-21 R-HSA-9857375 MITF dimerizes BibTex
2023-12-21 R-MMU-9857363 MiT family members dimerize BibTex
2023-12-21 R-HSA-9858646 TCF/LEF:CTNNB1 binds the CCND1 gene BibTex
2023-12-21 R-HSA-9858647 HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter BibTex
2023-12-21 R-HSA-9858645 MITF-M and CTNNB1-dependent CCND1 expression BibTex
2023-12-21 R-HSA-9858650 MITF-M dimer binds the CCND1 gene BibTex
2023-12-21 R-HSA-9858643 MITF-M dimer binds the CCNB1 gene BibTex
2023-12-21 R-HSA-9858641 MITF-M-dependent CCNB1 gene expression BibTex
2023-12-21 R-HSA-9858652 MITF-M dimer binds the CDKN2A gene BibTex
2023-12-21 R-HSA-9858651 MITF-M-dependent expression of CDKN2A gene product 16INK4A BibTex
2023-12-21 R-HSA-9858566 MITF-M-dependent CDK2 expression BibTex
Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand BibTex
Reviewed Reactions (15/15)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618099 NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-9725885 P4 bind PGR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9690534 NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
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