TP53 binds ARG1 gene

Stable Identifier
R-HSA-9959857
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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TP53 binds ARG1 gene
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TP53 binds to the ARG1 genomic region to repress transcription as assessed by ChIP and reporter gene assay (Li et al, 2019). TP53-mediated downregulation of urea cycle genes contributes to cellular proliferation by increasing the levels of polyamines like putrescine through an ammonia-dependent upregulation of ornithine decarboxylase (ODC) translation, the key enzyme in polyamine synthesis (Li et al, 2019; reviewed in Holbert et al, 2022).
Literature References
PubMed ID Title Journal Year
30842655 p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis

Li, L, Mao, Y, Zhao, L, Li, L, Wu, J, Zhao, M, Du, W, Yu, L, Jiang, P

Nature 2019
35477776 Polyamines in cancer: integrating organismal metabolism and antitumour immunity

Holbert, CE, Cullen, MT, Casero, RA, Stewart, TM

Nat Rev Cancer 2022
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Authored
Rothfels, K  (2025-07-02)
Created
Rothfels, K  (2025-07-02)
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